The biology of platelets, fibrin and blood-derived preparations
Platelets carry growth factors, adhesion proteins and small signaling molecules in their granules, and release them when activated. Platelet-rich plasma and platelet-rich fibrin concentrate those components, marrow and adipose preparations gather other cell populations, and the way each is made determines what it contains.
These references explain that biology and the preparation science behind it for clinicians and researchers, with numbered citations to the peer-reviewed literature on every page.
The references, in reading order
6 references, each with numbered citations to the peer-reviewed literature.
What platelets carry and how cells read it
The granules platelets store, the proteins they release on activation, and the receptors on neighboring cells that read those signals.
How preparations are made and described
The variables that make one platelet or cell preparation differ from another, what marrow and adipose preparations contain, and the reporting standards that make studies comparable.
PRP Preparation Variables: Spin, Platelet Dose and Leukocytes
Why PRP preparations differ, and how to describe them.
Bone Marrow Aspirate Concentrate and Adipose SVF: Composition
Cell composition of marrow and fat preparations.
How Platelet Studies Report Methods: PRP Reporting Standards
Reporting standards for platelet studies.
This page is provided for informational purposes only. It is not medical advice, it is not intended to diagnose, treat, cure, or prevent any disease, and it is not a substitute for the judgment of a licensed practitioner. Consult a healthcare professional before acting on anything stated here. ExaVeyra Sciences is a supplier and takes no part in any diagnosis, treatment decision, or plan of care. These references describe platelet, fibrin and blood-derived cell biology and preparation science for professional education, and make no statement about the efficacy or composition of any product or device. There are no FDA-approved exosome products. Biomolecular signaling vesicle products distributed by ExaVeyra Sciences are supplied for topical aesthetic use by licensed practitioners and for laboratory and IND-authorized clinical research, are not intended to diagnose, treat, cure, mitigate or prevent any disease, and, as secreted cell products, are not tissue products (HCT/Ps) under 21 CFR 1271.3(d)(3).