Explore Exosome Components

Research models associate exosomal miR-146a with improved diabetic wound closure, angiogenesis, collagen deposition, and inflammatory-pathway modulation.

• miR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1.

  DOI: 10.1038/s41392-022-01263-w

• Exosomes derived from adipose stem cells enhance angiogenesis in diabetic wound via the miR-146a-5p/JAZF1 axis.

  DOI: 10.1007/s12015-024-10685-8

• Development of microRNA-146a-enriched stem cell secretome for wound-healing applications.

  DOI: 10.1021/acs.molpharmaceut.9b00639

Extracellular-vesicle let-7 signaling is studied for anti-fibrotic, anti-inflammatory, autophagy, and neural-regeneration effects across tissue-repair models.

• Mesenchymal stem cells deliver exogenous microRNA-let7c via exosomes to attenuate renal fibrosis.

  DOI: 10.1038/mt.2016.90

• LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b.

  DOI: 10.1186/s12967-015-0642-6

• Micro-RNA let-7a-5p derived from mesenchymal stem cell-derived extracellular vesicles promotes neuron regrowth after spinal cord injury.

  DOI: 10.3389/fnmol.2022.850364

Peer-reviewed work links exosomal miR-21 to fibroblast activity, angiogenesis, PI3K/Akt pathway activation, and wound-repair signaling.

• Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function.

  DOI: 10.7150/thno.21234

• Roles of microRNA-21 in skin wound healing: a comprehensive review.

  DOI: 10.3389/fphar.2022.828627

• MiR-21/PTEN axis promotes skin wound healing by dendritic cells enhancement.

  DOI: 10.1002/jcb.26026

Exosomal miR-125b is studied for aged-wound repair, fibroblast migration, angiogenic signaling, and moderation of scar-related TGF-beta pathways.

• Young fibroblast-derived exosomal microRNA-125b transfers beneficial effects on aged cutaneous wound healing.

  DOI: 10.1186/s12951-022-01348-2

• UCB-MSC-derived exosomal miR-21-5p and miR-125b-5p inhibit myofibroblast differentiation by suppressing TGF-beta receptor signaling.

  DOI: 10.1186/s13287-021-02517-0

• Effects of intensive glycemic control on serum exosome miR-126-3p and miR-125b-1-3p levels and wound healing in patients with diabetic ulcers.

  DOI: 10.1155/2023/2523245

miR-29a is widely studied as an anti-fibrotic regulator of extracellular-matrix remodeling, collagen production, and tissue-repair signaling.

• Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a.

  DOI: 10.4252/wjsc.v16.i2.191

• Mesenchymal cell-derived exosomes and miR-29a-3p mitigate renal fibrosis and vascular rarefaction after renal ischemia reperfusion injury.

  DOI: 10.1186/s13287-025-04226-4

• MicroRNA-29 family, a crucial therapeutic target for fibrosis diseases.

  DOI: 10.1016/j.biochi.2013.03.010

Extracellular-vesicle transfer of miR-143/145 is associated with vascular smooth-muscle communication, vascular homeostasis, and atheroprotective signaling in research models.

• Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.

  DOI: 10.1038/ncb2441

• Extracellular vesicles mediate communication between endothelial and vascular smooth muscle cells.

  DOI: 10.3390/ijms23010331

• Extracellular vesicle microRNA transfer in cardiovascular disease.

  DOI: 10.1016/j.yjmcc.2015.04.007